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Search results (642)

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Lead optimisation of OXS007417: in vivo PK profile and hERG liability modulation to optimise a small molecule differentiation agent for the potential treatment of acute myeloid leukaemia.

Cogswell TJ. et al, (2024), RSC Med Chem, 15, 3495 - 3506

β-Peptides incorporating polyhydroxylated cyclohexane β-amino acid: synthesis and conformational study.

Reza D. et al, (2023), Org Biomol Chem, 21, 8535 - 8547

General Approach to Enantiopure 1-Aminopyrrolizidines: Application to the Asymmetric Synthesis of the Loline Alkaloids.

Davies SG. et al, (2023), J Org Chem, 88, 8093 - 8098

Microgrewiapine C: Asymmetric Synthesis, Spectroscopic Data, and Configuration Assignment.

Davies SG. et al, (2022), J Nat Prod, 85, 1872 - 1879

Synthesis and Configuration of O-Acetyl Microgrewiapine A: Phantomization of O-Acetyl 6-epi-Microgrewiapine A.

Davies SG. et al, (2022), J Nat Prod, 85, 306 - 312

A phenotypic screen identifies a compound series that induces differentiation of acute myeloid leukemia cells in vitro and shows antitumor effects in vivo

Josa-Culleré L. et al, (2021), Journal of Medicinal Chemistry

Mutual kinetic resolution: probing enantiorecognition phenomena and screening for kinetic resolution with racemic reagents.

Davies SG. et al, (2021), Org Biomol Chem, 19, 2847 - 2855

Decreasing HepG2 Cytotoxicity by Lowering the Lipophilicity of Benzo[d]oxazolephosphinate Ester Utrophin Modulators.

Chatzopoulou M. et al, (2020), ACS Med Chem Lett, 11, 2421 - 2427

2-Arylbenzo[d]oxazole Phosphinate Esters as Second-Generation Modulators of Utrophin for the Treatment of Duchenne Muscular Dystrophy.

Babbs A. et al, (2020), Journal of medicinal chemistry, 63, 7880 - 7891

Chemical Proteomics and Phenotypic Profiling Identifies the Aryl Hydrocarbon Receptor as a Molecular Target of the Utrophin Modulator Ezutromid.

Wilkinson IVL. et al, (2020), Angew Chem Int Ed Engl, 59, 2420 - 2428

Synthesis of SMT022357 enantiomers and in vivo evaluation in a Duchenne muscular dystrophy mouse model.

Babbs A. et al, (2020), Tetrahedron, 76

Asymmetric syntheses of fagomine and its stereoisomers

Davies SG. et al, (2019), Tetrahedron, 75

The asymmetric synthesis of (S,S)-methylphenidate hydrochloride via ring-opening of an enantiopure aziridinium intermediate with phenylmagnesium bromide

Davies SG. et al, (2019), Tetrahedron, 75

Asymmetric synthesis of the allocolchicinoid natural product N-acetylcolchinol methyl ether (suhailamine), solid state and solution phase conformational analysis

Davies SG. et al, (2019), Tetrahedron, 75

Isolation, structural identification, synthesis, and pharmacological profiling of 1,2-trans-dihydro-1,2-diol metabolites of the utrophin modulator ezutromid

Chatzopoulou M. et al, (2019), Journal of Medicinal Chemistry, 63, 2547 - 2556

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