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The objective of this study was to test the efficacy of intravenously administered S-adenosyl-L-methionine (SAMe) in patients with fibromyalgia (FM). Thirty-four out-patients with fibromyalgia symptoms received SAMe 600 mg i.v. or placebo daily for 10 days in a cross-over trial. There was no significant difference in improvement in the primary outcome: tender point change between the two treatment groups. There was a tendency towards statistical significance in favour of SAMe on subjective perception of pain at rest (p = 0.08), pain on movement (p = 0.11), and overall well-being (p = 0.17) and slight improvement only on fatigue, quality of sleep, morning stiffness, and on the Fibromyalgia Impact Questionnaire for pain. No effect could be observed on isokinetic muscle strength, Zerrsen self-assessment questionnaire, and the face scale. No effect of SAMe in patients with FM was found in this short term study.

Original publication




Journal article


Scand J Rheumatol

Publication Date





206 - 211


Adult, Aged, Cross-Over Studies, Double-Blind Method, Female, Fibromyalgia, Humans, Injections, Intravenous, Male, Middle Aged, Pain, Pain Measurement, S-Adenosylmethionine, Severity of Illness Index, Surveys and Questionnaires, Treatment Outcome