Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology.
Horsburgh K., Wardlaw JM., van Agtmael T., Allan SM., Ashford MLJ., Bath PM., Brown R., Berwick J., Cader MZ., Carare RO., Davis JB., Duncombe J., Farr TD., Fowler JH., Goense J., Granata A., Hall CN., Hainsworth AH., Harvey A., Hawkes CA., Joutel A., Kalaria RN., Kehoe PG., Lawrence CB., Lockhart A., Love S., Macleod MR., Macrae IM., Markus HS., McCabe C., McColl BW., Meakin PJ., Miller A., Nedergaard M., O'Sullivan M., Quinn TJ., Rajani R., Saksida LM., Smith C., Smith KJ., Touyz RM., Trueman RC., Wang T., Williams A., Williams SCR., Work LM.
Cerebral small vessel disease (SVD) is a major contributor to stroke, cognitive impairment and dementia with limited therapeutic interventions. There is a critical need to provide mechanistic insight and improve translation between pre-clinical research and the clinic. A 2-day workshop was held which brought together experts from several disciplines in cerebrovascular disease, dementia and cardiovascular biology, to highlight current advances in these fields, explore synergies and scope for development. These proceedings provide a summary of key talks at the workshop with a particular focus on animal models of cerebral vascular disease and dementia, mechanisms and approaches to improve translation. The outcomes of discussion groups on related themes to identify the gaps in knowledge and requirements to advance knowledge are summarized.