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During NMR experiments on isolated, perfused rat heart, we observed a 57% change in probe sensitivity when the perfusion buffer surrounding the heart was replaced by either a low-ionic-strength mannitol solution or air and the heart was made ischemic. Such changes in sensitivity, should they go unrecognized, would result in substantial quantification errors.

Original publication

DOI

10.1002/mrm.1910270214

Type

Journal article

Journal

Magn Reson Med

Publication Date

10/1992

Volume

27

Pages

343 - 348

Keywords

Air, Animals, Cardioplegic Solutions, Glucose, Magnetic Resonance Spectroscopy, Male, Mannitol, Myocardial Ischemia, Myocardium, Organophosphonates, Osmolar Concentration, Perfusion, Rats, Rats, Sprague-Dawley, Tromethamine