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© 2008 by Imperial College Press. Monitoring of cell status and tissue formation within a three-dimensional cultured tissue is important to the success of engineered tissue development. Here we describe a method using microdialysis probes for the continuous monitoring of local extracellular environment, cell metabolic activity, cell functions and possible tissue formation. Using 3D culture of chondrocytes and culture of intervertebral disc explant as examples, the effectiveness of this method is demonstrated. Challenges and practical issues in using this method are discussed as well.

Original publication





Book title

Advances in Tissue Engineering

Publication Date



401 - 420