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The term nociception was originally defined by Sherrington1 as the neural process by which high-threshold stimuli (which cause tissue injury) are detected. This is distinct from pain, which is defined by the quality of the sensory percept (i.e., unpleasant), is not always evoked by a noxious stimulus, and can also be experienced in the absence of a noxious stimulus. In man, recessive loss of function mutations in the SCN9A gene, encoding the α subunit of Nav1.7, results in anosmia and the congenital inability to experience pain,2–4 but there have been few reports of detailed sensory testing in these patients.

Original publication

DOI

10.1212/WNL.0000000000000913

Type

Journal article

Journal

Neurology

Publisher

American Academy of Neurology

Publication Date

21/10/2014