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Rearrangements which are most readily explained by homologous crossover between misaligned segments of DNA in the region of the human embryonic zeta (zeta) globin genes have been identified in individuals of three different racial origins. These recombination events have resulted in a surprisingly high prevalence of chromosomes with single (0.4%) and triplicated (1.3%) zeta genes with apparently no significant effect on the phenotype.


Journal article


Nucleic Acids Res

Publication Date





5853 - 5868


Chromosomes, Human, 16-18 Crossing Over (Genetics) DNA Restriction Enzymes Embryo Female *Genes, Structural Human Nucleic Acid Hybridization Pregnancy Racial Stocks Support, Non-U.S. Gov't Thalassemia/genetics