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An introduction to mathematical models of pattern formation by morphogen gradients is presented, using the early embryo of the fruit fly Drosophila as the main experimental example. Analysis of morphogen gradient formation is based on the source-diffusion-degradation models and a formalism of local accumulation times. Transcriptional control by morphogens is discussed within the framework of thermodynamic site occupancy models of gene regulatory regions.

Original publication

DOI

10.1002/wdev.55

Type

Journal article

Journal

Wiley Interdiscip Rev Dev Biol

Publication Date

09/2012

Volume

1

Pages

715 - 730

Keywords

Animals, Drosophila, Embryonic Development, Gene Expression Regulation, Developmental, Models, Theoretical, Morphogenesis, Signal Transduction