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The conserved homeobox (Hox) gene cluster is neither conserved nor clustered in the nematode Caenorhabditis elegans. Instead, C. elegans has a reduced and dispersed gene complement that is the result the loss of Hox genes in stages throughout its evolutionary history. The roles of Hox genes in patterning the nematode body axis are also divergent, although there are tantalising remnants of ancient regulatory systems. Hox patterning also differs greatly between C. elegans and a second 'model' nematode, Pristionchus pacificus. The pattern of Hox gene evolution may be indicative of the move to deterministic developmental modes in nematodes.

Original publication

DOI

10.1016/j.gde.2003.10.009

Type

Journal article

Journal

Curr Opin Genet Dev

Publication Date

12/2003

Volume

13

Pages

593 - 598

Keywords

Animals, Artificial Gene Fusion, Biometry, Evolution, Molecular, Gene Deletion, Genes, Homeobox, Nematoda