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The acronym CANOMAD encompasses chronic ataxic neuropathy combined with ophthalmoplegia, M protein, cold agglutinins, and anti-disialosyl antibodies.Herein we describe 2 patients presenting with progressive ataxic neuropathy who only developed ophthalmoplegia after a significant delay post-presentation, which in 1 case had features indicative of brainstem dysfunction. Both patients were found to have an IgM paraprotein and anti-disialosyl antibodies. They responded to treatment with intravenous immunoglobulin, thus illustrating the importance of diagnosing this condition.

Original publication




Journal article


Muscle Nerve

Publication Date





829 - 833


Adult, Aged, Anemia, Hemolytic, Autoimmune, Ataxia, Diagnosis, Differential, Female, Humans, Immunoglobulins, Intravenous, Male, Ophthalmoplegia