Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

A technique for immunoelectronmicroscopy has been used to investigate major histocompatibility class II expression in leprosy nerves. In normal nerves, endothelial cells and occasional endoneural cells (not Schwann cells) were constitutively class II positive. In both paucibacillary and multibacillary leprosy nerve biopsies, infiltrating leukocytes were positive but class II-positive Schwann cells were not seen. These observations indicate that Schwann cells may not be involved in presenting Mycobacterium leprae antigens to T cells in leprosy. This conflicts with evidence from in vitro studies, but may be explained by the fact that in vivo Schwann cells are surrounded by basement membranes and are closely associated with axons.

Type

Journal article

Journal

Int J Lepr Other Mycobact Dis

Publication Date

09/1990

Volume

58

Pages

560 - 565

Keywords

Antigen-Presenting Cells, Endothelium, Fibroblasts, Histocompatibility Antigens Class II, Humans, Immunohistochemistry, Leprosy, Lymphocytes, Macrophages, Microscopy, Electron, Peripheral Nerves