Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Blockade of CD40-CD154 interactions can facilitate long-term allograft acceptance in selected rodent and in primate models, but, due to the ability of CD154-independent CD8(+) T cells to initiate graft rejection, this strategy is not always effective. In this work we demonstrate that blockade of the CD40-CD154 pathway at the time of transplantation enables the generation of donor alloantigen-specific CD4(+)CD25(+) regulatory T cells, and that if the regulatory cells are present in sufficient numbers they can suppress allograft rejection mediated by CD154-independent CD8(+) T cells.

Original publication




Journal article


J Immunol

Publication Date





5401 - 5404


Adoptive Transfer, Animals, Antibodies, Monoclonal, CD4 Antigens, CD4-Positive T-Lymphocytes, CD40 Antigens, CD40 Ligand, CD8-Positive T-Lymphocytes, Epitopes, T-Lymphocyte, Graft Rejection, Heart Transplantation, Injections, Intraperitoneal, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Inbred CBA, Mice, Inbred NZB, Mice, Knockout, Mice, Transgenic, Receptors, Interleukin-2, Skin Transplantation, T-Lymphocyte Subsets