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We describe an α-thalassemia determinant in which α-globin expression is silenced by a deletion located 27 kb 5' to the transcription start site of the α2-globin gene. This α-thalassemic determinant, (αα)(MM), is a member of a newly described group of thalassemic mutations resulting from deletion of locus-controling sequences critical to globin gene expression.

Original publication

DOI

10.1182/blood.v78.6.1589.bloodjournal7861589

Type

Journal article

Journal

Blood

Publication Date

01/01/1991

Volume

78

Pages

1589 - 1595