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Summary. We have studied the interaction of the ααα/αα gene arrangement with various β globin genotypes (AA, AS, AC, SS and SC). Whereas this interaction has no detectable clinical or haematological effects in subjects with AA, SS or SC genotypes it is associated with a significantly increased level of Hb S or Hb C in heterozygotes for these variants. These findings indicate that the additional α globin gene in the ααα gene arrangement is functional. Copyright © 1984, Wiley Blackwell. All rights reserved

Original publication

DOI

10.1111/j.1365-2141.1984.tb08556.x

Type

Journal article

Journal

British Journal of Haematology

Publication Date

01/01/1984

Volume

57

Pages

671 - 678