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An asymmetric synthesis of an advanced intermediate in the synthesis of natural (-)-pumiliotoxin C has been achieved in six steps and in 61% overall yield employing as the key step a highly diastereoselective lithium amide 1,4-conjugate addition to a dienoic ester derived from (R)-(+)-pulegone.

Original publication

DOI

10.1016/0957-4166(96)00190-5

Type

Journal article

Journal

Tetrahedron Asymmetry

Publication Date

01/01/1996

Volume

7

Pages

1595 - 1596