Bifunctional chiral auxiliaries 3: Synthesis of homochiral 1,3-diols via asymmetric aldol reactions of dialkylboron enolates of 1,3-dipropionyl-trans-4,5-diphenyl-imidazolidin-2-one and aldehydes
Davies SG., Mortlock AA.
Dibutylboron enolates derived from both racemic and homochiral 1,3-dipropionyl-trans-4,5-diphenylimidazolidin-2-one 3 react with aldehydes in highly diastereoselective dialdol reactions to give, after reductive cleavage of the acyl sidechain, substituted 1,3-diols. © 1991.