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Investigations reveal that the structures assigned to D-α-amino acid containing diketopiperazines (DKPs) 21-25 isolated from the sponge Calyx CF. podatypa have been reported incorrectly. Synthetic studies and comparison with literature data have enabled the structures of these DKPs to be correctly reassigned. Evidence is presented to suggest that naturally occurring D-Pro-L-Xxx-DKPs are artifacts resulting from non-enzymatic epimerisation of the corresponding L-Pro-L-Xxx-DKP natural products.

Original publication




Journal article


Journal of the Chemical Society - Perkin Transactions 1

Publication Date



2313 - 2320