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The conjugate addition of (R)-N-methyl-N-α-methylbenzyl amide to tert-butyl cinnamate followed by an asymmetric aldol reaction and subsequent N-oxidation/Cope elimination affords β-substituted homochiral Baylis-Hillman products in good yield. Copyright (C) 2000 Elsevier Science Ltd.

Original publication

DOI

10.1016/S0957-4166(00)00224-X

Type

Journal article

Journal

Tetrahedron Asymmetry

Publication Date

30/06/2000

Volume

11

Pages

2437 - 2441