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Palladium catalysed coupling reactions of 6-O-tert-butyldimethylsilyl-1-bromocodeine and 6-O-tert-butyldimethylsilyl-3-trifluoromethylsulfonylmorphine allow a range of substituted analogues of codeine in the 1-position and morphine in the 3-position to be efficiently and selectively prepared.

Original publication

DOI

10.1039/b102581n

Type

Journal article

Journal

Journal of the Chemical Society. Perkin Transactions 1

Publication Date

01/01/2001

Pages

1413 - 1420