Lithium amide conjugate addition for the asymmetric synthesis of 3-aminopyrrolidines.
Davies SG., Garner AC., Goddard EC., Kruchinin D., Roberts PM., Rodriguez-Solla H., Smith AD.
Conjugate addition of homochiral lithium amides to methyl 4-(N-benzyl-N-allylamino)but-2-enoate, chemoselective N-deprotection and concomitant cyclisation, followed by enolate functionalisation and deprotection allows access to syn- and anti-3,4-disubstituted aminopyrrolidines in > 98% d.e. and > 98% e.e.