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Conjugate addition of homochiral lithium amides to methyl 4-(N-benzyl-N-allylamino)but-2-enoate, chemoselective N-deprotection and concomitant cyclisation, followed by enolate functionalisation and deprotection allows access to syn- and anti-3,4-disubstituted aminopyrrolidines in > 98% d.e. and > 98% e.e.

Original publication

DOI

10.1039/b604835h

Type

Journal article

Journal

Chem Commun (Camb)

Publication Date

05/07/2006

Pages

2664 - 2666