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Asymmetric syntheses of fagomine and its stereoisomers

Davies SG., Fletcher AM., Roberts PM., Thomson JE.

© 2019 Elsevier Ltd D-Fagomine (1,2,5-trideoxy-1,5-imino-d-arabino-hexitol), a naturally occurring polyhydroxylated piperidine (iminosugar), and its stereoisomers display important biological activities such as glycosidase inhibition. This review delineates both de novo asymmetric and enantiospecific syntheses of fagomine and its stereoisomers.

Original publication

DOI

10.1016/j.tet.2019.130727

Type

Journal article

Journal

Tetrahedron

Publication Date

13/12/2019

Volume

75