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Artificial nanoparticles accumulate a protein corona layer in biological fluids, which significantly influences their bioactivity. As nanosized obligate intracellular parasites, viruses share many biophysical properties with artificial nanoparticles in extracellular environments and here we show that respiratory syncytial virus (RSV) and herpes simplex virus type 1 (HSV-1) accumulate a rich and distinctive protein corona in different biological fluids. Moreover, we show that corona pre-coating differentially affects viral infectivity and immune cell activation. In addition, we demonstrate that viruses bind amyloidogenic peptides in their corona and catalyze amyloid formation via surface-assisted heterogeneous nucleation. Importantly, we show that HSV-1 catalyzes the aggregation of the amyloid β-peptide (Aβ42), a major constituent of amyloid plaques in Alzheimer's disease, in vitro and in animal models. Our results highlight the viral protein corona as an acquired structural layer that is critical for viral-host interactions and illustrate a mechanistic convergence between viral and amyloid pathologies.

Original publication

DOI

10.1038/s41467-019-10192-2

Type

Journal article

Journal

Nature communications

Publication Date

27/05/2019

Volume

10

Pages

2331 - 2331

Addresses

Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, 10691, Sweden. kariem.ezzat@su.se.

Keywords

Cell Line, Tumor, Vero Cells, Bronchoalveolar Lavage Fluid, Animals, Mice, Transgenic, Cercopithecus aethiops, Humans, Mice, Herpesvirus 1, Human, Respiratory Syncytial Virus, Human, Herpes Simplex, Respiratory Syncytial Virus Infections, Alzheimer Disease, Disease Models, Animal, Peptide Fragments, Female, Male, Host-Pathogen Interactions, Amyloid beta-Peptides, Healthy Volunteers, Protein Aggregates, Protein Corona