Head of James & Lillian Martin Centre
Sally is a Wellcome Trust Career Re-Entry Fellow, engaged in a program of research into the differentiation of human Embryonic Stem (hES) cells along the myeloid pathway. She has set up (with William James) and is Head of the James and Lillian Martin Centre for Stem Cell Research within the Sir William Dunn School of Pathology, University of Oxford (affiliated to the Oxford Stem Cell Institute) for work with hES cells and human induced Pluripotent Stem cells (iPSc). She supervises collaborative projects within this Facility, including: the differentiation of iPSc from Chronic Granulomatous Disease patients into macrophages, (CGD Research Trust); the generation of iPSc from people with Parkinson's (Oxford Parkinson's Disease Centre, Parkinson’s UK).
Induced Pluripotent Stem cells (iPSC) derived from patients with genetic disease offers a new, hugely exciting opportunity to model human diseases in vitro. iPSC are particularly important for modelling neurological conditions, where patient material is generally unavailable until after death, and for rare genetic disorders, where patient material is severely limiting.
To harness this potential, I have established and am Head of the James and Lillian Martin Centre for Stem Cell Research (within the Sir William Dunn School of Pathology, University of Oxford, and part of the Oxford Stem Cell Institute), with particular interests in the use of iPSC for modelling disease, and expertise in human iPSC derivation, genetic modification, and differentiation to myeloid and neuronal lineages.
C9orf72-ALS human iPSC microglia are pro-inflammatory and toxic to co-cultured motor neurons via MMP9
Vahsen B. et al, (2023), Nature Communications
Calcium dysregulation combined with mitochondrial failure and electrophysiological maturity converge in Parkinson's iPSC-dopamine neurons.
Beccano-Kelly DA. et al, (2023), iScience, 26
PTCH1mutant human cerebellar organoids are associated with altered neural development and early pathways of medulloblastoma oncogenesis
van Essen MJ. et al, (2023)
Post-translational proteomics platform identifies neurite outgrowth impairments in Parkinson’s disease GBA-N370S dopamine neurons
RYAN B., (2023), Cell Reports
Single-cell transcriptomics defines an improved, validated monoculture protocol for differentiation of human iPSC to microglia.
Washer SJ. et al, (2022), Sci Rep, 12