Research groups
Websites
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MRC Molecular Haematology Unit
Research Unit
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MRC Weatherall Institute of Molecular Medicine
Research Institute
Roger Patient
Visiting Professor of Developmental Genetics
Blood and cardiovascular development, with a particular focus on stem cells. Transcriptional network assembly in response to embryonic signals. Xenopus and zebrafish models.
Key publications
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MiR-142-3p controls the specification of definitive hemangioblasts during ontogeny
Journal article
Nimmo R. et al, (2013), Developmental Cell, 26, 237 - 249
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VEGFA-dependent and -independent pathways synergise to drive Scl expression and initiate programming of the blood stem cell lineage in Xenopus.
Journal article
Ciau-Uitz A. et al, (2013), Development, 140, 2632 - 2642
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Uncoupling VEGFA functions in arteriogenesis and hematopoietic stem cell specification.
Journal article
Leung A. et al, (2013), Dev Cell, 24, 144 - 158
Recent publications
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The roles and controls of GATA factors in blood and cardiac development
Conference paper
Patient R. et al, (2019)
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Blood stem cell-forming haemogenic endothelium in zebrafish derives from arterial endothelium.
Journal article
Bonkhofer F. et al, (2019), Nat Commun, 10
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An optimised pipeline for parallel image-based quantification of gene expression and genotyping after in situ hybridisation
Journal article
(2019), Biology Open
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Etv6 activates vegfa expression through positive and negative transcriptional regulatory networks in Xenopus embryos.
Journal article
Li L. et al, (2019), Nat Commun, 10
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New methods for computational decomposition of whole-mount in situ images enable effective curation of a large, highly redundant collection of Xenopus images.
Journal article
Patrushev I. et al, (2018), PLoS Comput Biol, 14