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Contact information


george.tofaris@ndcn.ox.ac.uk


+44 (0)1865 234 304
Fax +44(0)1865 234 837


Ellie Slattery (NHS)
Neurology.Parkinsons@ouh.nhs.uk

Biography

George Tofaris graduated from the combined MB/PhD programme of Cambridge University (Trinity College) in 2003. He completed his general medical training at the National Hospital for Neurology, Hammersmith, Royal Brompton and Royal Free hospitals in London in 2006. He worked for a year at the Neurology Department of the Austin hospital, an affiliate of Melbourne University. He was appointed Clinical Lecturer at Oxford in 2007 and completed his training in Clinical Neurology in 2011 with subspecialty training in Movement Disorders at the National Hospital for Neurology and Neurosurgery. Between 2008-09, he was a Lefler Fellow in Cell Biology at Harvard Medical School. In 2012, he was awarded a Wellcome Trust Intermediate Clinical Fellowship and the Wellcome-Beit Prize to further his research and after a short visit at the Brigham and Women's Hospital in Boston, he established his research group at Oxford. In 2020, he was awarded an MRC Senior Clinical Fellowship. He also established and led the EU IMI Consortium IMPRiND which investigated mechanisms relevant to the progression of pathology in Parkinson's and Alzheimer's disease. He held a Medical Research Fellowship at Corpus Christi College and previously a Todd-Bird Junior Research Fellowship in Medicine at New College. As a clinically active Consultant Neurologist at the John Radcliffe hospital, he covers acute as well as general outpatient neurology and leads regional specialist clinics in Movement and Neurogenetic Disorders. He is also the Oxford PI for Clinical Trials testing precision therapies in Parkinson's disease. 

George Tofaris

PhD, MBBChir, FRCP

Professor of Neurology and Translational Neuroscience

  • MRC Senior Clinical Fellow
  • Honorary Consultant Neurologist

Molecular mechanisms of neurodegeneration

Research Summary

My research aim is to delineate cellular pathways in protein quality control that could inform the development of novel biomarkers and targeted therapies in neurodegenerative and neurogenetic disorders. To this end, my group is currently using forward genetics, proteomics and transcriptomics in models of increasing cellular complexity, including patient-derived induced pluripotent stem cells (iPSC).

Of particular interest to my group is the cellular trafficking and aggregation of α-synuclein, a key protein in Parkinson's disease. We found that α-synuclein is ubiquitinated in human brain and discovered that this modification regulates the localisation of α-synuclein to endosomes for degradation by lysosomes. We have developed iPSC-based models to identify modifiers of its turnover and aggregation. 

Our studies inside cells suggested a rationale for endosome-derived extracellular vesicle alpha-synuclein  as a biomarker in Parkinson's disease.  We have developed improved methodologies to immunocapture neuronally-derived extracellular vesicles from serum and performed multi-centre studies demonstrating their value in the prediction and stratification of Parkinson's and related conditions.

We are also interested in the role of mitochondrial dysfunction in hereditary forms of neurodegeneration. 

Key publications

Recent publications