Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Accept all cookies Reject all non-essential cookies Find out more

Contact information


elizabeth.robertson@path.ox.ac.uk

Elizabeth Robertson

Professor of Developmental Biology

Transcriptional regulators of mammalian development

Our research exploits mouse genetics to investigate the key signalling cues and transcriptional regulators governing cell fate decisions in the developing mammalian embryo. In particular, we have been studying the TGF family of secreted growth factors, including the ligand Nodal, and its downstream effector Smad2, responsible for patterning the anterior-posterior or "head-tail" axis of the embryo. Similarly, BMP/Smad1 signals are essential for germ cell specification.

Blimp1 expression marks developing forelimb buds, secondary heart field and gut tube.Blimp1 expression marks developing forelimb buds, secondary heart field and gut tube.
Nodal/Smad2 activate Eomes upstream of Mesp1/2 mesoderm or later in the endodermNodal/Smad2 activate Eomes upstream of Mesp1/2 mesoderm or later in the endoderm

Our recent work has focused on target genes of these pathways that play critical roles in diverse tissue contexts. We are investigating how the T-box transcription factor Eomesodermin functions downstream of Nodal/Smad2 to orchestrate cell fate allocation during gastrulation, and governs trophoblast stem cell maintenance. Additionally, we are studying Blimp1, a PR-SET domain Zn-finger transcriptional repressor, downstream in the BMP/Smad1 pathway. We aim to understand how this master regulator influences the local chromatin landscape at its target genes during trophoblast giant cell differentiation in the developing placenta, and globally regulates post-natal reprogramming of gene expression in the intestinal epithelium.

We use transgenic and embryonic stem (ES) cell technologies to dissect the conserved cis-acting regulatory elements present at the promoter and enhancer regions of these genes that direct their temporally and spatially restricted expression patterns. We have generated novel knock-in mouse strains for in vivo live cell imaging and fate mapping studies. A panel of mutant ES and TS cell lines is available for transcriptional profiling and ChIP experiments.

Our long-term goal is to learn more about the molecular and cellular mechanisms that govern tissue morphogenesis in an orderly fashion as cells diversity and acquire specialized functions within the embryo.