Websites
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MRC Weatherall Institute of Molecular Medicine
Research Institute
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MRC Molecular Haematology Unit
Research Unit
Adam Mead
PhD FRCP FRCPath FMedSci
Professor of Haematology
- Consultant Physician
- CRUK Senior Cancer Research Fellow
Normal and malignant haematopoietic stem cell biology
Normal and malignant haematopoietic stem cell biology
I trained in medicine and haematology at the University of Oxford and UCL and completed my PhD at UCL in 2007. I am currently funded by a CRUK Senior Cancer Research Fellowship.
The overarching focus of my research group is to characterise genetic and cellular heterogeneity in myeloproliferative neoplasms (MPN) and related myeloid neoplasms with the ultimate goal to improve the diagnosis, risk-stratification and treatment of these largely incurable forms of blood cancer. Our work using cutting edge techniques in single cell genomics and in vivo models has revealed hitherto unrecognised heterogeneity of cancer stem cells, including a key role for inflammation in promoting therapy resistance and genetic evolution. Understanding the interplay between genetic, metabolic and inflammatory factors in the clonal evolution of myeloid malignancies is now the key focus of my research group.
My research is closely linked with my clinical practice based at Oxford University Hospitals NHS Trust where I am myeloid clinical lead. I am or have been the principal/chief investigator for over 50 trials. I led the development of JAK2 inhibitor therapies in the UK for patients with MPN as chief investigator, scientific lead or co-investigator on multiple key clinical trials (ROBUST, MAJIC, MITHRIDATE, PERSIST-1 and -2, MPDRC114, PHAZAR, PAC203, FEDORA, PROMise).
Key publications
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Journal article
Li R. et al, (2024), Sci Transl Med, 16
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Journal article
Rodriguez-Meira A. et al, (2023), Nat Genet
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Journal article
Harrison CN. et al, (2023), J Clin Oncol
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Journal article
Sousos N. et al, (2022), Nat Med, 28, 1207 - 1211
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Journal article
Louka E. et al, (2021), Journal of Experimental Medicine, 218
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Single-cell analyses reveal aberrant pathways for megakaryocyte-biased hematopoiesis in myelofibrosis and identify mutant clone-specific targets
Journal article
ROBERTS I. et al, (2020), Molecular Cell
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Journal article
Rodriguez-Meira A. et al, (2019), Mol Cell, 73, 1292 - 1305.e8
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Journal article
Giustacchini A. et al, (2017), Nat Med, 23, 692 - 702
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Journal article
Booth CAG. et al, (2018), Cancer cell, 33, 274 - 291.e8
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Journal article
Mead AJ. et al, (2012), N Engl J Med, 366, 967 - 969
Recent publications
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Journal article
Li R. et al, (2024), Sci Transl Med, 16
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Journal article
Godfrey AL. et al, (2024), Br J Haematol
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Journal article
Gerds AT. et al, (2024), Blood Adv
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Journal article
Carrelha J. et al, (2024), Nat Immunol
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Journal article
Oh ST. et al, (2024), EJHaem, 5, 105 - 116
ORC-ID
0000-0001-8522-1002