Syntheses of (R)-sitagliptin
Davies SG., Fletcher AM., Thomson JE.
© 2015 Elsevier Ltd. All rights reserved. In the last 10 years, since Merck's discovery and development of (R)-sitagliptin phosphate as a treatment for type 2 diabetes, numerous efforts towards efficient synthesis of (R)-sitagliptin have been reported. In this review, several total syntheses of (R)-sitagliptin are described, highlighting the key stereoselective and stereospecific strategies employed.