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© 2015 Elsevier Ltd. All rights reserved. In the last 10 years, since Merck's discovery and development of (R)-sitagliptin phosphate as a treatment for type 2 diabetes, numerous efforts towards efficient synthesis of (R)-sitagliptin have been reported. In this review, several total syntheses of (R)-sitagliptin are described, highlighting the key stereoselective and stereospecific strategies employed.

Original publication

DOI

10.1016/j.tetasy.2015.09.010

Type

Journal article

Journal

Tetrahedron Asymmetry

Publication Date

01/11/2015

Volume

26

Pages

1109 - 1116