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We have characterised a cluster of CpG rich (HTF) islands in the alpha-globin complex and report here two unusual features: The human embryonic zeta 2-globin gene is associated with an HTF island within its 3' portion rather than at the 5' end. Furthermore at least two non-functional pseudogenes within the cluster (psi zeta 1 and psi alpha 2) are associated with CpG rich islands.


Journal article


Nucleic Acids Res

Publication Date





9215 - 9225


Animal Base Sequence Comparative Study Cytidine Monophosphate/analogs & derivatives Cytosine DNA Restriction Enzymes *Genes, Structural Globins/*genetics Guanine Guanosine/analogs & derivatives Human *Pseudogenes Species Specificity