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This article covers N-acyl chiral auxiliary-based approaches to the asymmetric synthesis of enantiopure aldehydes and ketones. The use of diastereoisomerically pure N-acyl derivatives of chiral auxiliaries (including chiral Weinreb amide equivalents) and their conversion to the corresponding enantiopure aldehydes and ketones in a single synthetic operation by treatment with a hydride reducing agent or an organometallic reagent, respectively, are highlighted.

Original publication

DOI

10.1039/c3cc45463k

Type

Journal article

Journal

Chem Commun (Camb)

Publication Date

07/10/2013

Volume

49

Pages

8586 - 8598