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Motivated by experimental work (Miller et al. in Biomaterials 27(10):2213-2221, 2006, 32(11):2775-2785, 2011) we investigate the effect of growth factor driven haptotaxis and proliferation in a perfusion tissue engineering bioreactor, in which nutrient-rich culture medium is perfused through a 2D porous scaffold impregnated with growth factor and seeded with cells. We model these processes on the timescale of cell proliferation, which typically is of the order of days. While a quantitative representation of these phenomena requires more experimental data than is yet available, qualitative agreement with preliminary experimental studies (Miller et al. in Biomaterials 27(10):2213-2221, 2006) is obtained, and appears promising. The ultimate goal of such modeling is to ascertain initial conditions (growth factor distribution, initial cell seeding, etc.) that will lead to a final desired outcome.

Original publication

DOI

10.1007/s11538-013-9810-0

Type

Journal article

Journal

Bull Math Biol

Publication Date

03/2013

Volume

75

Pages

393 - 427

Keywords

Bioreactors, Cell Culture Techniques, Cell Growth Processes, Humans, Intercellular Signaling Peptides and Proteins, Models, Biological, Tissue Engineering, Tissue Scaffolds