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Schistosomes cause significant morbidity and mortality. In this article, we discuss recent findings regarding how different schistosome species infect and manipulate immune responses in their hosts through the evolution and use of different protease classes. The advent of transgenic schistosomes is explored in relation to the biology of these important molecules.

Original publication

DOI

10.1016/j.pt.2008.01.003

Type

Journal article

Journal

Trends Parasitol

Publication Date

04/2008

Volume

24

Pages

153 - 156

Keywords

Animals, Evolution, Molecular, Host-Parasite Interactions, Humans, Molecular Biology, Organisms, Genetically Modified, Peptide Hydrolases, Schistosoma, Schistosomiasis, Serine Endopeptidases