Combination dual responsive polypeptide vectors for enhanced gene delivery.
Nasanit R., Iqbal P., Soliman M., Spencer N., Allen S., Davies MC., Briggs SS., Seymour LW., Preece JA., Alexander C.
Variation in amino acid sequences on a disulfide-linked polypeptide backbone generates differing pK(a) vectors for DNA delivery, which release nucleic acids under reducing conditions and transfect cells with greater efficacy than non-reducible or non-variable pK(a) analogues.