A modular RNA delivery system comprising spherical nucleic acids built on endosome-escaping polymeric nanoparticles
Garcia-Guerra A., Ellerington R., Gaitzsch J., Bath J., Kye M., Varela MA., Battaglia G., Wood MJA., Manzano R., Rinaldi C., Turberfield AJ.
Polymeric spherical nucleic acids comprise pH-sensitive, polymer-conjugated oligonucleotides that self-assemble into nanoparticles with the ability to escape endosomes, overcoming a major obstacle in nucleic acid delivery.