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Bunyamwera virus and snowshoe have virus (family Bunyaviridae) were passaged up to six times through mosquito cells in culture and the resultant viruses were compared to the input, mammalian cell-passed virus using monoclonal antibodies raised against the input virus. The mosquito cell-adapted virus population consisted of mutants which were better adapted to replication in the new host than was the input mammalian cell-passed virus and were differentially susceptible to neutralization by antibody.

Original publication




Journal article


J Gen Virol

Publication Date



67 ( Pt 12)


2803 - 2806


Aedes, Animals, Antibodies, Monoclonal, Antibodies, Viral, Antigens, Viral, Bunyamwera virus, Bunyaviridae, Cell Line, Chlorocebus aethiops, Epitopes, Genes, Viral, Mutation, Neutralization Tests, Viral Envelope Proteins, Viral Plaque Assay, Virus Replication