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The synthesis of a series of chiral auxiliaries, 5-substituted-3,3-dimethyl-2-pyrrolidinones, "quats", from L-glutamic acid is described. Efficient regeneration of the chiral auxiliaries from their N-pivaloyl derivatives is readily achieved with LiOH in THF-water at 20°C. © 1994.

Original publication

DOI

10.1016/0040-4039(94)85222-7

Type

Journal article

Journal

Tetrahedron Letters

Publication Date

11/04/1994

Volume

35

Pages

2369 - 2372