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(2S,3S)- and (2R,3S)-2,3-diaminobutanoic acids (DABA) are uncommon, naturally occurring amino acid diastereomers found as components of a number of peptide antibiotics. These 2,3-diamino acids have been synthesised by direct and indirect routes, with addition of a chiral lithium amide to tert-butyl crotonate as a key step.

Original publication

DOI

10.1055/s-1996-5556

Type

Journal article

Journal

Synlett

Publication Date

01/01/1996

Volume

1996

Pages

621 - 622