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Michael addition of the lithium amide derived from R-N-(α-methylbenzyl)benzylamine to benzyl E-crotonate is highly stereoselective (95% d.e.) giving after debenzylation and crystallisation homochiral R-β-amino butanoic acid. A similar addition to methyl E-(p-benzyloxy)cinnamate is completely stereoselective giving after debenzylation and acid hydrolysis homochiral S-β-tyrosine as its HCl salt. © 1993.

Original publication

DOI

10.1016/S0957-4166(00)82354-X

Type

Journal article

Journal

Tetrahedron: Asymmetry

Publication Date

01/01/1991

Volume

2

Pages

183 - 186