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Schollkopf's auxiliary 16 was added to bis-lactim iodide 21 to give 1,2- bis[(3S,6R)-3,6-dihydro-2,5-dimethoxy-3-isopropylpyrazin-6-yl]ethane 22 in 50% d.e. Dimer 22 was separated from its diastereoisomer 23 and deprotected using 6M HCl to afford homochiral (2R,5R)-2,5-diaminohexan-1,6-dioic acid 24.

Original publication

DOI

10.1016/S0040-4020(98)00492-X

Type

Journal article

Journal

Tetrahedron

Publication Date

27/08/1998

Volume

54

Pages

10379 - 10388