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We present an example of applying 'need-driven' product design principle to the development of a rapid test kit to detect SARS-COV-2 (COVID-19). The tests are intended for use in the field and, longer term, for home use. They detect whether a subject is currently infected with the virus and is infectious. The urgent need for large numbers of tests in field setting imposes constraints such as short test time and lack of access to specialist equipment, laboratories and skilled technicians to perform the test and interpret results. To meet these needs, an antigen test based on RT-LAMP with colorimetric readout was chosen. Direct use of swab sample with no RNA extraction was explored. After extensive experimental study (reported elsewhere), a rapid test kit has been fabricated to satisfy all design criteria.

Original publication

DOI

10.1007/s42242-020-00075-7

Type

Journal article

Journal

Biodes Manuf

Publication Date

11/05/2020

Pages

1 - 4

Keywords

Antigen detection, COVID-19, Product design, RT-LAMP, Rapid test, SAR-Cov-2