SF3B1 mutations induce R-loop accumulation and DNA damage in MDS and leukemia cells with therapeutic implications.

Singh S., Ahmed D., Dolatshad H., Tatwavedi D., Schulze U., Sanchi A., Ryley S., Dhir A., Carpenter L., Watt SM., Roberts DJ., Abdel-Aal AM., Sayed SK., Mohamed SA., Schuh A., Vyas P., Killick S., Kotini AG., Papapetrou EP., Wiseman DH., Pellagatti A., Boultwood J.

DOI

10.1038/s41375-020-0753-9

Type

Journal article

Journal

Leukemia

Publication Date

09/2020

Volume

34

Pages

2525 - 2530

Keywords

DNA Damage, Humans, Mutation, Myelodysplastic Syndromes, Phosphoproteins, R-Loop Structures, RNA Splicing Factors

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