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© 2019 The Japan Institute of Heterocyclic Chemistry Received Conjugate addition of heteroaryl substituted lithium amides to a range of α,β-unsaturated esters followed by in situ enolate oxidation with (-)-(camphorsulfonyl)oxaziridine gave the corresponding α-hydroxy-β-amino esters. Subsequent Friedel-Crafts type cyclisation of these α-hydroxy-β-amino esters gave a range of heteroarene-fused azacycles in good yields and high diastereoselectivities.

Original publication

DOI

10.3987/COM-18-S(F)59

Type

Journal article

Journal

Heterocycles

Publication Date

01/01/2019

Volume

99

Pages

919 - 941