Oxford Stem Cell Institute

Therapeutic manipulation and spatial quantification of the tumor microenvironment in colorectal cancer.

Mulholland-Illingworth EJ. et al, (2026), iScience, 29

Upstream ORFs control TNFR1 abundance and tissue tolerance to TNF.

Ma B. et al, (2026), Sci Immunol, 11

Metabolite-induced DNA damage drives stochastic stem cell loss and clonal hematopoiesis.

Kamimae-Lanning AN. et al, (2026), Cell Stem Cell, 33, 642 - 659.e11

A novel EYS c.6192-1G>A variant presents ideal base editing therapeutic opportunities.

Kaukonen M. et al, (2026), Ophthalmic Genet, 47, 195 - 198

IMPG2-associated retinal dystrophy with a novel missense variant and therapeutic options via adenine base editing.

Abdalla Elsayed MEA. et al, (2026), Ophthalmic Genet, 47, 172 - 178

Tracking tau and cellular responses in human iPSC-microglia: from uptake to seedable secretion, including in extracellular vesicles.

Karabova MK. et al, (2026), Alzheimers Dement, 22

Serum p-tau217 Is a Prognostic Indicator of Cognitive Impairment in Idiopathic REM Sleep Behavior Disorder.

Yan S. et al, (2026), Ann Neurol, 99, 912 - 921

Facilitators may represent a new class of regulatory elements.

Kassouf M. et al, (2026), Curr Opin Genet Dev, 97

Myeloproliferative neoplasms with concomitant chronic myeloid leukemia are associated with TKI resistance and poor outcomes.

Gagnon LL. et al, (2026), Leukemia

MYB activity drives emergent enhancer activation and enhancer-promoter interactions in acute lymphoblastic leukemia.

Lau I-J. et al, (2026), Blood

Vitrectomy and internal limiting membrane peeling for extensive macular schisis in choroideremia.

Abdalla Elsayed MEA. et al, (2026), Graefes Arch Clin Exp Ophthalmol

A functional overlap between actively transcribed genes and chromatin insulator elements.

Cornell LJ. et al, (2026), EMBO J

Dopamine release from Parkinson’s patient-derived neurons is disrupted due to impaired synaptic vesicle loading

Cramb KML. et al, (2026)

Design, validation, and functional impact of oligonucleotides for multigene silencing in Alzheimer's disease.

Woffindale C. et al, (2026), Mol Ther Nucleic Acids, 37

Gain and Loss of FLT3 Mutations in Patients with Acute Myeloid Leukemia: A Noninterventional Cohort Study (CLEVO).

Papayannidis C. et al, (2026), Oncol Ther

Targeted BDNF upregulation via upstream open reading frame disruption.

Feng N. et al, (2026), Mol Ther, 34, 1652 - 1671

Mutational Signatures and Clonal Hematopoiesis in Intestinal Metaplasia across Countries with Varying Stomach Cancer Incidence.

Huang KK. et al, (2026), Cancer Discov, 16, 497 - 520

Genome-wide association study of neuropathic pain.

Spildrejorde M. et al, (2026), Pain, 167, 731 - 738

Ancestry and somatic profile indicate acral melanoma origin and prognosis.

Basurto-Lozada P. et al, (2026), Nature, 651, 221 - 230

Compartment-specific correlation of pathological α-synuclein in prodromal Parkinson's disease.

Röttgen S. et al, (2026), Parkinsonism Relat Disord, 144

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