Diastereoselective conjugate additions to alkoxycarbene cations of the iron chiral auxiliary [(η5-C5H5)Fe(CO)(PPh3)C(OMe)CHCHR]+
Davies SG., Easton RJC., McKenna JM., Polywka MEC., Thomson JE.
Abstract The conjugate additions of alkyllithium reagents to alkoxycarbene cations of the iron chiral auxiliary [(η5-C5H5)Fe(CO)(PPh3)C(OMe)CHCHR]+ proceeded with moderate to excellent diastereoselectivity. The resultant methoxyvinyl complexes were transformed into the corresponding iron acyl complexes following a sequence of protonation and demethylation. The overall transformation yields iron acyl complexes of opposite relative configuration to those which result from the conjugate addition of the same nucleophile to the corresponding α,β-unsaturated iron acyl complex.