Synthesis of 5-substituted-3,3-dimethyl-2-pyrrolidinones: "quat" chiral auxiliaries
Davies SG., Doisneau GJM., Prodger JC., Sanganee HJ.
The synthesis of a series of chiral auxiliaries, 5-substituted-3,3-dimethyl-2-pyrrolidinones, "quats", from L-glutamic acid is described. Efficient regeneration of the chiral auxiliaries from their N-pivaloyl derivatives is readily achieved with LiOH in THF-water at 20°C. © 1994.