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© 2016 IOP Publishing Ltd.Migration of cells and molecules in vivo is affected by interactions with obstacles. These interactions can include crowding effects, as well as adhesion/repulsion between the motile cell/molecule and the obstacles. Here we present an analytical framework that can be used to separately quantify the roles of crowding and adhesion/repulsion using a lattice-based random walk model. Our method leads to an exact calculation of the long time Fickian diffusivity, and avoids the need for computationally expensive stochastic simulations.

Original publication

DOI

10.1088/1478-3975/13/5/05LT02

Type

Journal article

Journal

Physical Biology

Publication Date

06/09/2016

Volume

13