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Oxford Stem Cell Institute Symposium 2018

Stem Cells: From Mechanism to Therapy

St Hugh’s College 12-13 November

Michele de Luca, Modena 
 René Hen, New York 
 Michael Young, Boston 
 Molly Stevens, London 
 Angela Russell, Oxford 
 Bertie Göttgens, Cambridge 
 Tom Milne, Oxford 
 Marlen Knobloch, Lausanne 
 Ludovic Vallier, Cambridge 
 Colin Goding, Oxford

Dominique Bonnet, London 
 Michael Schneider, London 
 Joo Hyeon-Lee, Cambridge 
 Julie Davies, Oxford 
 Amanda Carr, London 
 Andy Carr, Oxford 
 Roger Barker, Cambridge 
 Lorna Fiedler & Sophia Malandraki-Miller, Oxford 
 Helen Knowles, Oxford 
 Alun Barnard, Oxford

The Symposium will highlight areas of stem cell research with trajectories towards treatments of diseases including retinopathies, metabolic and genetic skin disorders, neurodegeneration, musculoskeletal disease, heart failure and cancer.

Stem Cells, Regenerative Medicine and Cancer

One of the greatest challenges of the 21st century is disease associated with ageing. Cancer, neurodegeneration and heart disease are all major causes of death and have an enormous impact on quality of life.

Over recent years, a revolution in biology has meant that effective regenerative medicine, using stem cells to replace and repair damaged tissue is now on the horizon. Naturally occurring ‘immortal’ stem cells are present in all tissues of the body and act to replace loss of cells in tissues with rapid turnover, for example in the skin, blood or intestine, or to repair damage as in wound healing.

Harnessing the power of stem cells to regenerate damaged tissue in a range of diseases, or to generate tissue for organ repair following radical surgery, is a key goal. Yet how we can effectively manipulate stem cells for therapeutic use, and how we ensure their survival, for example after transplantation, remain major challenges.

The identification of physiological stem cells that regenerate tissues led to the discovery of stem-like cells in cancer. Cancer stem cells are resistant to therapy and provide a reservoir of cells able to regenerate tumours with their associated genetic heterogeneity, even many years after apparently successful therapy. Understanding the origins of cancer stem cells, how they are activated, and how they can be eradicated are key goals that must be met if we are to develop effective anti-cancer therapies.

The Oxford Stem Cell Institute (OSCI) was established in 2008 with funding from the Oxford Martin School and seeded multiple interdisciplinary collaborations and facilitated applications for substantial external funding. The OSCI comprises over 45 core and affiliated  laboratories across Oxford and recognizes that the development of more effective stem cell and anti-cancer therapies would benefit from cross-disciplinary research that breaks the traditional taxonomic barriers boundaries between cancer, development and regenerative medicine.

Events

CRUK Oxford Cancer Centre Symposium - June 15th, 2018

Mathematical Institute

The 7th Annual Cancer Centre Symposium showcases the strength and breadth of Oxford's cancer research programme and features cross-departmental and interdisciplinary partnerships supporting translational cancer research. The Symposium also provides opportunities to network and establish new collaborations.For registration see: https://www.eventbrite.co.uk/e/7th-cancer-research-uk-oxford-centre-2018-symposium-tickets-44982207995

Richard Gardner Lecture - November 9th, 2018  Prof  Pier Giuseppe Pelicci

MSTC Auditorium   16.00

Pier Giuseppe Pelicci is a world leader in stem cell research, his laboratory has contributed to the preliminary understanding of the self-renewal properties of cancer stem cells (in leukemias and mammary tumors), showing that they possess: i) increased replicative potential due to the up-regulation of the cell-cycle inhibitor p21 and the prevention of excess DNA-damage accumulation; ii) increased frequency of symmetric divisions, due to p53 inactivation.

For examples of his recent work see: http://www.ifom-ieo-campus.it/research/pelicci.php

 

Oxford Stem Cell Institute Annual Symposium - November 12th and 13th , 2018

St Hugh's College, University of Oxford

The two-day symposium takes place in the prestigious St Hugh's College  in the heart of Oxford. The meeting is showcasing presentations by leading scientists in stem cells research.

Register

Download the Symposium Program

Download the Symposium Poster