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Oxford Stem Cell Institute Symposium 2019

Stem Cells: From Mechanism to Therapy

St John’s College 17-18 September

Philippe Menasche, Paris 
 Sten Eirik Jacobsen, Stockholm 
 Eduard Batlle, Barcelona 
 Francesco Saverio Tedesco, London 
 Paul Riley, Oxford 
 Maria Pilar Alcolea, Cambridge 
 Francis Szele, Oxford 
 Ana Martin-Villalba, Heidelberg 
 Florian Merkle, Cambridge 
 

Colin Goding, Oxford 
 J.P Martinez-Barbera, London 
 Siim Pauklin, Oxford 
 Alberto Baena Lopez, Oxford 
 Paola Bonfanti, London 
 Stuart Forbes, Edinburgh 
 Catherine Porcher, Oxford 
 Richard Wade-Martins, Oxford 
 Shukry Habib-King, London 
 

The Symposium will highlight areas of stem cell research with trajectories towards treatments of diseases including metabolic and genetic skin disorders, neurodegeneration, musculoskeletal disease, heart failure and cancer.

Stem Cells, Regenerative Medicine and Cancer

One of the greatest challenges of the 21st century is disease associated with ageing. Cancer, neurodegeneration and heart disease are all major causes of death and have an enormous impact on quality of life.

Over recent years, a revolution in biology has meant that effective regenerative medicine, using stem cells to replace and repair damaged tissue is now on the horizon. Naturally occurring ‘immortal’ stem cells are present in all tissues of the body and act to replace loss of cells in tissues with rapid turnover, for example in the skin, blood or intestine, or to repair damage as in wound healing.

Harnessing the power of stem cells to regenerate damaged tissue in a range of diseases, or to generate tissue for organ repair following radical surgery, is a key goal. Yet how we can effectively manipulate stem cells for therapeutic use, and how we ensure their survival, for example after transplantation, remain major challenges.

The identification of physiological stem cells that regenerate tissues led to the discovery of stem-like cells in cancer. Cancer stem cells are resistant to therapy and provide a reservoir of cells able to regenerate tumours with their associated genetic heterogeneity, even many years after apparently successful therapy. Understanding the origins of cancer stem cells, how they are activated, and how they can be eradicated are key goals that must be met if we are to develop effective anti-cancer therapies.

The Oxford Stem Cell Institute (OSCI) was established in 2008 with funding from the Oxford Martin School and seeded multiple interdisciplinary collaborations and facilitated applications for substantial external funding. The OSCI comprises over 45 core and affiliated  laboratories across Oxford and recognizes that the development of more effective stem cell and anti-cancer therapies would benefit from cross-disciplinary research that breaks the traditional taxonomic barriers boundaries between cancer, development and regenerative medicine.

Events

Stem Cells UK - October 1st, 2019

will be held at the Francis Crick Institute, 1 Midland Road, London, NW1 1AT.

The Francis Crick Institute, the Centre for Regenerative Medicine (Edinburgh) and the Cambridge Stem Cell Institute are pleased to be organising the first Stem Cells UK meeting.

This one-day meeting aims to bring together stem cell researchers from across the UK to share research findings, forge collaborations and meet friends, old and new!

The day will feature excellent UK-based speakers, with plenty of time for networking and informal interactions.

Confirmed speakers include:  Bertie Gottgens, Shukry Habib, Majlinda Lako, Madeline Lancaster, Joo-Hyeon Lee, Cristina Lo Celso, Donal O’Carroll, Katrin Ottersbach, Simona Parrinello, Wolf Reik, Paul Riley, Abdenour Soufi.

The venue is fully accessible and babies are welcome, with a parenting room available.

More information and full programme can be found here:  www.stemcells.cam.ac.uk/events/scuk

For registration see: https://onlinesales.admin.cam.ac.uk/conferences-and-events/stem-cell-institute/stem-cells-uk-2019/stem-cells-uk-2019

Richard Gardner Lecture - November 1st, 2019  Prof  Michele De Luca

MSTC Auditorium   16.00

Professor De Luca, and his principal collaborator Graziella Pellegrini, have been involved in epithelial stem cell biology aimed at clinical application in regenerative medicine for over 20 years. Beside his work on the use of human epidermal stem cell cultures in life-saving treatment of massive full-thickness burns and in repigmentation of stable vitiligo and piebaldism, he established human limbal stem cell culture aimed at corneal regeneration in patients with severe limbal stem cell deficiency. This treatment leads to recovery of vision in patients with poor alternative options for therapy. Michele De Luca is currently coordinating the first (successful) ex-vivo epithelial stem cell-mediated gene therapy clinical trial for the gene therapy of junctional epidermolysis bullosa, a serious genetic skin disease. He is also studying molecular mechanisms regulating self-renewal, proliferative potential and clonal evolution of epithelial stem cells.

Interview with Michele De Luca – Epithelial cells and regrowing corneal epithelium16.00

 https://www.eurostemcell.org/interview-michele-de-luca-epithelial-cells-and-regrowing-corneal-epithelium

 

Oxford Stem Cell Institute Annual Symposium - September 17th and 18th , 2019

St  John's College, University of Oxford

The two-day symposium takes place in the prestigious St John's College  in the heart of Oxford. The meeting is showcasing presentations by leading scientists in stem cells research.

Abstracts

If you wish to submit an abstract, please email to: olga.perestenko@stemcells.ox.ac.uk

Abstract submission deadline is 10th September. Poster specifications: posters should be printed in A0 portrait format.

Register

Download the Symposium Program

Download the Symposium Poster