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Several neuronal populations orchestrate neocortical development during mammalian embryogenesis. These include the glutamatergic subplate-, Cajal-Retzius-, and ventral pallium-derived populations, which coordinate cortical wiring, migration, and proliferation, respectively. These transient populations are primarily derived from other non-cortical pallial sources that migrate to the dorsal pallium. Are these migrations to the dorsal pallium conserved in amniotes or are they specific to mammals? Using in ovo electroporation, we traced the entire lineage of defined chick telencephalic progenitors. We found that several pallial sources that produce tangential migratory neurons in mammals only produced radially migrating neurons in the avian brain. Moreover, ectopic expression of VP-specific mammalian Dbx1 in avian brains altered neurogenesis but did not convert the migration into a mammal-like tangential movement. Together, these data indicate that tangential cellular contributions of glutamatergic neurons originate from outside the dorsal pallium and that pallial Dbx1 expression may underlie the generation of the mammalian neocortex during evolution.

Original publication

DOI

10.1016/j.celrep.2017.12.032

Type

Journal article

Journal

Cell Reports

Publisher

Elsevier

Publication Date

02/01/2018

Volume

22

Pages

96 - 109

Addresses

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, UK; Achucarro Basque Center for Neuroscience, Parque Científico UPV/EHU Edif. Sede, 48940 Leioa, Spain; IKERBASQUE Foundation, María Díaz de Haro 3, 6th Floor, 48013 Bilbao, Spain. Electronic address: fernando.garcia-moreno@achucarro.org.