Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

CD45 is crucial for normal lymphocyte signalling, and altered CD45 expression has major effects on immune function. Both mice and humans lacking CD45 expression are severely immunodeficient, and single-nucleotide polymorphisms in the CD45 gene that cause altered splicing have been associated with autoimmune and infectious diseases. Recently, we identified an exon 6 A138G polymorphism resulting in an increased proportion of activated CD45RO T cells and altered immune function. Here we report a significantly reduced frequency of the 138G allele in hepatitis C Japanese patients and a possibly reduced frequency in type I diabetes. The allele is widely distributed in the Far East and India, indicating that it may have a significant effect on disease burden in a large part of the human population.

Original publication

DOI

10.1007/s00251-006-0099-0

Type

Journal article

Journal

Immunogenetics

Publication Date

04/2006

Volume

58

Pages

235 - 239

Keywords

Communicable Diseases, Diabetes Mellitus, Type 1, Exons, Far East, Gene Frequency, Hepatitis C, Humans, India, Japan, Leukocyte Common Antigens, Molecular Epidemiology, Polymorphism, Single Nucleotide, Protein Tyrosine Phosphatase, Non-Receptor Type 1